Reference - Detail
| RRC ID | 78426 |
|---|---|
| Author | Liu Y, Min Y, Liu Y, Watanabe Y. |
| Title | Phosphorylation of Rec8 cohesin complexes regulates mono-orientation of kinetochores in meiosis I. |
| Journal | Life Sci Alliance |
| Abstract |
In meiosis I, unlike in mitosis, sister kinetochores are captured by microtubules emanating from the same spindle pole (mono-orientation) and centromeric cohesion mediated by cohesin is protected in the following anaphase I. The conserved meiosis-specific kinetochore protein meikin (Moa1 in fission yeast) associates with polo-like kinase: Plo1 and regulates both mono-orientation and cohesion protection. Although the phosphorylation of Rec8-S450 by Plo1 associated with Moa1 plays a key role in cohesion protection, how Moa1-Plo1 regulates mono-orientation remains elusive. Here, we identify Plo1 phosphorylation sites in the cohesin subunits, Rec8 and Psm3. The non-phosphorylatable mutations at these sites showed specific defects in mono-orientation. These results enabled the genetic dissection of meikin functions at the centromeres. |
| Volume | 7(5) |
| Published | 2024-5-1 |
| DOI | 10.26508/lsa.202302556 |
| PII | 7/5/e202302556 |
| PMID | 38448160 |
| PMC | PMC10917647 |
| MeSH | Cell Cycle Proteins / genetics Centromere Cohesins Kinetochores Meiosis Phosphorylation Protein Serine-Threonine Kinases Schizosaccharomyces* / genetics Schizosaccharomyces pombe Proteins* / genetics |
| IF | 2.622 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 4 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Yeast | |