論文 - 詳細
| RRC ID | 78570 |
|---|---|
| 著者 | Hachiya K, Deguchi Y, Hirata T, Arikawa T, Fukai H, Esashi T, Nagasawa K, Mizunoe Y, Nozaki Y, Kobayashi M, Higami Y. |
| タイトル | Obesity-induced PARIS (ZNF746) accumulation in adipose progenitor cells leads to attenuated mitochondrial biogenesis and impaired adipogenesis. |
| ジャーナル | Sci Rep |
| Abstract |
White adipose tissue (WAT) is critical for whole-body energy metabolism, and its dysfunction leads to various metabolic disorders. In recent years, many studies have suggested that impaired mitochondria may contribute to obesity-related decline in adipose tissue function, but the detailed mechanisms remain unclear. To investigate these mechanisms, we carried out a comprehensive analysis of WAT from mice with diet-induced obesity. We discovered the transcription factor Parkin interactive substrate (PARIS or ZNF746), which suppresses the expression of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), a key regulator of mitochondrial biogenesis, to be accumulated in adipose progenitor cells from obese mice. Furthermore, we demonstrated that 3T3-L1 preadipocytes with overexpression of PARIS protein exhibited decreased mitochondrial biogenesis and impaired adipogenesis. Our results suggest that the accumulation of PARIS protein may be a novel component in the pathogenesis of obesity-related dysfunction in WAT. |
| 巻・号 | 13(1) |
| ページ | 22990 |
| 公開日 | 2023-12-27 |
| DOI | 10.1038/s41598-023-49996-0 |
| PII | 10.1038/s41598-023-49996-0 |
| PMID | 38151567 |
| PMC | PMC10752882 |
| MeSH | 3T3-L1 Cells Adipogenesis* Adipose Tissue, White / metabolism Animals Mice Obesity / metabolism Organelle Biogenesis* Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / genetics Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / metabolism Stem Cells / metabolism Transcription Factors / metabolism |
| IF | 3.998 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 遺伝子材料 | CS-CDF-CG-PRE (RDB04379) |