論文 - 詳細
| RRC ID | 78608 |
|---|---|
| 著者 | Takemoto K, Ganlin T, Iji M, Narukawa T, Koyama T, Hao L, Watanabe H. |
| タイトル | Vegetable Extracts as Therapeutic Agents: A Comprehensive Exploration of Anti-Allergic Effects. |
| ジャーナル | Nutrients |
| Abstract |
Food allergies are common worldwide and have become a major public health concern; more than 220 million people are estimated to suffer from food allergies worldwide. On the other hand, polyphenols, phenolic substances found in plants, have attracted attention for their health-promoting functions, including their anti-allergic effects. In this study, we examined the potential inhibitory effects of 80% ethanol extracts from 22 different vegetables on the degranulation process in RBL-2H3 cells. Our aim was to identify vegetables that could prevent and treat type I allergic diseases. We found strong inhibition of degranulation by extracts of perilla and chives. Furthermore, we verified the respective efficacy via animal experiments, which revealed that the anaphylactic symptoms caused by ovalbumin (OVA) load were alleviated in OVA allergy model mice that ingested vegetable extracts of perilla and chives. These phenomena were suggested to be caused by induction of suppression in the expression of subunits that constitute the high-affinity IgE receptor, particularly the α-chain of FcεR I. Notably, the anti-allergic effects of vegetables that can be consumed daily are expected to result in the discovery of new anti-immediate allergenic drugs based on the components of these vegetables. |
| 巻・号 | 16(5) |
| 公開日 | 2024-2-29 |
| DOI | 10.3390/nu16050693 |
| PII | nu16050693 |
| PMID | 38474821 |
| PMC | PMC10933941 |
| MeSH | Animals Anti-Allergic Agents* / pharmacology Food Hypersensitivity* / drug therapy Humans Immunoglobulin E / metabolism Mast Cells Mice Mice, Inbred BALB C Plant Extracts / pharmacology Vegetables / metabolism |
| IF | 4.546 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RBL 2H3(RCB2782) |