論文 - 詳細
| RRC ID | 78618 |
|---|---|
| 著者 | Usukhbayar N, Takano Y, Uesugi S, Muroi M, Osada H, Kimura KI. |
| タイトル | 3,6-Epidioxy-1,10-bisaboladiene induces ferroptosis-like cell death through lipid peroxidation. |
| ジャーナル | Free Radic Res |
| Abstract |
3,6-Epidioxy-1,10-bisaboladiene (EDBD) is a bisabolane sesquiterpene endoperoxide that was isolated from an edible wild plant in Japan, Cacalia delphiniifolia. It showed partially apoptotic cell death through caspase activation against HL-60 cells. However, almost all of the cells had necrotic morphology. Thus, we examined the mechanism of action of EDBD on necrotic cell death. EDBD induced ferrous ion-dependent cell death which causes cell membrane damage, and its cell death form was like H2O2-induced necrosis in HL-60 cells. The oxidative stress-induced necrosis inhibitor IM-54 prevented EDBD-induced cell death, but it was not blocked by either caspase inhibitor, z-VAD-fmk, or necroptosis inhibitor, necrostatin-1. Furthermore, EDBD induced lipid peroxidation in a time- and dose-dependent manner and was inhibited with both ferrostatin-1 and α-tocopherol. EDBD also downregulated GPX4, the primary cell defense protein against lipid peroxidation, and decreased GSH levels. Taken together, these results suggest that EDBD induces ferrous ion-dependent ferroptosis-like cell death through lipid peroxidation. |
| 巻・号 | 57(3) |
| ページ | 208-222 |
| 公開日 | 2023-12-1 |
| DOI | 10.1080/10715762.2023.2229005 |
| PMID | 37347979 |
| MeSH | Caspases Cell Death Ferroptosis* Humans Hydrogen Peroxide Iron Lipid Peroxidation Necrosis |
| IF | 2.839 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HL60(RCB0041) HP100-1(RCB0769) |