論文 - 詳細
| RRC ID | 78659 |
|---|---|
| 著者 | He C, Miyazawa T, Abe C, Ueno T, Suzuki M, Mizukami M, Kurihara K, Toda M. |
| タイトル | Hypolipidemic and Anti-Inflammatory Effects of Curcuma longa-Derived Bisacurone in High-Fat Diet-Fed Mice. |
| ジャーナル | Int J Mol Sci |
| Abstract |
Turmeric (Curcuma longa) contains various compounds that potentially improve health. Bisacurone is a turmeric-derived compound but has been less studied compared to other compounds, such as curcumin. In this study, we aimed to evaluate the anti-inflammatory and lipid-lowering effects of bisacurone in high-fat diet (HFD)-fed mice. Mice were fed HFD to induce lipidemia and orally administered bisacurone daily for two weeks. Bisacurone reduced liver weight, serum cholesterol and triglyceride levels, and blood viscosity in mice. Splenocytes from bisacurone-treated mice produced lower levels of the pro-inflammatory cytokines IL-6 and TNF-α upon stimulation with a toll-like receptor (TLR) 4 ligand, lipopolysaccharide (LPS), and TLR1/2 ligand, Pam3CSK4, than those from untreated mice. Bisacurone also inhibited LPS-induced IL-6 and TNF-α production in the murine macrophage cell line, RAW264.7. Western blot analysis revealed that bisacurone inhibited the phosphorylation of IKKα/β and NF-κB p65 subunit, but not of the mitogen-activated protein kinases, p38 kinase and p42/44 kinases, and c-Jun N-terminal kinase in the cells. Collectively, these results suggest that bisacurone has the potential to reduce serum lipid levels and blood viscosity in mice with high-fat diet-induced lipidemia and modulate inflammation via inhibition of NF-κB-mediated pathways. |
| 巻・号 | 24(11) |
| 公開日 | 2023-5-27 |
| DOI | 10.3390/ijms24119366 |
| PII | ijms24119366 |
| PMID | 37298318 |
| PMC | PMC10253162 |
| MeSH | Animals Anti-Inflammatory Agents / pharmacology Anti-Inflammatory Agents / therapeutic use Curcuma* / metabolism Cytokines / metabolism Diet, High-Fat / adverse effects Interleukin-6 Ligands Lipopolysaccharides / pharmacology Mice NF-kappa B* / metabolism Tumor Necrosis Factor-alpha |
| IF | 4.556 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |