| RRC ID |
78701
|
| 著者 |
Fujihashi Y, Jo Kim M, Maneenet J, Awale S.
|
| タイトル |
Piper longum Constituents Induce PANC-1 Human Pancreatic Cancer Cell Death under Nutrition Starvation.
|
| ジャーナル |
Chem Biodivers
|
| Abstract |
Pancreatic cancer is a highly aggressive form of cancer with a poor prognosis, partly due to 'austerity', a phenomenon of tolerance to nutrient deprivation and survival in its hypovascular tumor microenvironment. Anti-austerity agents which preferentially diminish the survival of cancer cells under nutrition starvation is regarded as new generation anti-cancer agents. This study investigated the potential of Piper longum constituents as anti-austerity agents. The ethanolic extract of Piper longum was found to have preferential cytotoxicity towards PANC-1 human pancreatic cancer cells in a nutrient-deprived medium (NDM). Further investigation led to the identification of pipernonaline (3) as the lead compound with the strongest anti-austerity activity, inducing cell death and inhibiting migration in a normal nutrient medium, as well as strongly inhibiting the Akt/mTOR/autophagy pathway. Therefore, pipernonaline (3) holds promise as a novel antiausterity agent for the treatment of pancreatic cancer.
|
| 巻・号 |
20(9)
|
| ページ |
e202300280
|
| 公開日 |
2023-9-1
|
| DOI |
10.1002/cbdv.202300280
|
| PMID |
37612242
|
| MeSH |
Antineoplastic Agents* / pharmacology
Antineoplastic Agents* / therapeutic use
Antineoplastic Agents, Phytogenic* / pharmacology
Cell Death
Cell Line, Tumor
Drug Screening Assays, Antitumor
Humans
Pancreatic Neoplasms* / drug therapy
Pancreatic Neoplasms* / pathology
Piper*
Tumor Microenvironment
|
| リソース情報 |
| ヒト・動物細胞 |
PANC-1(RCB2095) |
