論文 - 詳細
| RRC ID | 78701 |
|---|---|
| 著者 | Fujihashi Y, Jo Kim M, Maneenet J, Awale S. |
| タイトル | Piper longum Constituents Induce PANC-1 Human Pancreatic Cancer Cell Death under Nutrition Starvation. |
| ジャーナル | Chem Biodivers |
| Abstract |
Pancreatic cancer is a highly aggressive form of cancer with a poor prognosis, partly due to 'austerity', a phenomenon of tolerance to nutrient deprivation and survival in its hypovascular tumor microenvironment. Anti-austerity agents which preferentially diminish the survival of cancer cells under nutrition starvation is regarded as new generation anti-cancer agents. This study investigated the potential of Piper longum constituents as anti-austerity agents. The ethanolic extract of Piper longum was found to have preferential cytotoxicity towards PANC-1 human pancreatic cancer cells in a nutrient-deprived medium (NDM). Further investigation led to the identification of pipernonaline (3) as the lead compound with the strongest anti-austerity activity, inducing cell death and inhibiting migration in a normal nutrient medium, as well as strongly inhibiting the Akt/mTOR/autophagy pathway. Therefore, pipernonaline (3) holds promise as a novel antiausterity agent for the treatment of pancreatic cancer. |
| 巻・号 | 20(9) |
| ページ | e202300280 |
| 公開日 | 2023-9-1 |
| DOI | 10.1002/cbdv.202300280 |
| PMID | 37612242 |
| MeSH | Antineoplastic Agents* / pharmacology Antineoplastic Agents* / therapeutic use Antineoplastic Agents, Phytogenic* / pharmacology Cell Death Cell Line, Tumor Drug Screening Assays, Antitumor Humans Pancreatic Neoplasms* / drug therapy Pancreatic Neoplasms* / pathology Piper* Tumor Microenvironment |
| IF | 2.039 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | PANC-1(RCB2095) |