論文 - 詳細
| RRC ID | 78773 |
|---|---|
| 著者 | Fujimoto D, Shinohara M, Kawamori H, Toba T, Kakizaki S, Nakamura K, Sasaki S, Hamana T, Fujii H, Osumi Y, Hayasaka N, Kishino S, Ogawa J, Hirata KI, Otake H. |
| タイトル | The relationship between unique gut microbiome-derived lipid metabolites and subsequent revascularization in patients who underwent percutaneous coronary intervention. |
| ジャーナル | Atherosclerosis |
| Abstract |
BACKGROUND AND AIMS:Studies have recently revealed the linoleic acid metabolic pathway of Lactobacillus plantarum, the representative gut bacterium in human gastrointestinal tract, and the anti-inflammatory effects of metabolites in this pathway. However, no clinical trials have evaluated the association between these metabolites and revascularization in patients who underwent percutaneous coronary intervention (PCI). METHODS:We retrospectively reviewed patients who underwent PCI with subsequent revascularization or coronary angiography (CAG) without revascularization. Patients with frozen blood samples at the index PCI and revascularization or follow-up CAG were enrolled. RESULTS:Among 701 consecutive patients who underwent PCI, we enrolled 53 patients who underwent subsequent revascularization and 161 patients who underwent follow-up CAG without revascularization. Patients who underwent revascularization showed significantly lower plasma 10-oxo-octadecanoic acid (KetoB) levels (720.5 [551.6-876.5] vs. 818.4 [641.1-1103.6 pg/mL]; p = 0.01) at index PCI. Multivariate logistic regression analysis revealed that decreased plasma KetoB levels at the index PCI were independently associated with subsequent revascularization after PCI (odds ratio; 0.90 per 100 pg/mL increase, 95% confidence interval; 0.82-0.98). Additionally, in vitro experiments showed that the addition of purified KetoB suppressed the mRNA levels of IL-6 and IL-1β in macrophages and IL-1β mRNA in neutrophils. CONCLUSIONS:Plasma KetoB level at index PCI was independently associated with subsequent revascularization after PCI, and KetoB could act as an anti-inflammatory lipid mediator in macrophages and neutrophils. The assessment of gut microbiome-derived metabolites may help predict revascularization after PCI. |
| 巻・号 | 375 |
| ページ | 1-8 |
| 公開日 | 2023-6-1 |
| DOI | 10.1016/j.atherosclerosis.2023.05.001 |
| PII | S0021-9150(23)00184-3 |
| PMID | 37216727 |
| MeSH | Coronary Artery Bypass Gastrointestinal Microbiome* Humans Lipids Percutaneous Coronary Intervention* / adverse effects Retrospective Studies Risk Factors Treatment Outcome |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |