| RRC ID |
78782
|
| Author |
Sakamoto K, Uchiyama K, Iwasaki T, Inaba H, Matsuura K.
|
| Title |
An artificial viral capsid decorated with a DNA aptamer internalizing into lymphoma cells.
|
| Journal |
J Mater Chem B
|
| Abstract |
Tumor-specific drug-delivering nanocarriers could be a promising modality for next-generation tumor therapy. Here we developed a Burkitt lymphoma-specific DNA aptamer-labeled nanocarrier using the β-Annulus peptide, which forms a spherical nanoassembly called artificial viral capsid. Dynamic light scattering and transmission electron microscopy of the DNA aptamer-decorated artificial viral capsid showed the formation of spherical assemblies with a diameter of approximately 50-150 nm. The artificial viral capsid was selectively internalized into the Burkitt lymphoma cell line, Daudi, and doxorubicin complexed with the capsid selectively killed Daudi cells.
|
| Volume |
11(26)
|
| Pages |
6053-6059
|
| Published |
2023-7-5
|
| DOI |
10.1039/d3tb00169e
|
| PMID |
37310262
|
| MeSH |
Aptamers, Nucleotide*
Burkitt Lymphoma* / drug therapy
Capsid
Doxorubicin / pharmacology
Humans
Peptides
|
| Resource |
| Human and Animal Cells |
HeLa(RCB0007) |
