Reference - Detail
| RRC ID | 78782 |
|---|---|
| Author | Sakamoto K, Uchiyama K, Iwasaki T, Inaba H, Matsuura K. |
| Title | An artificial viral capsid decorated with a DNA aptamer internalizing into lymphoma cells. |
| Journal | J Mater Chem B |
| Abstract |
Tumor-specific drug-delivering nanocarriers could be a promising modality for next-generation tumor therapy. Here we developed a Burkitt lymphoma-specific DNA aptamer-labeled nanocarrier using the β-Annulus peptide, which forms a spherical nanoassembly called artificial viral capsid. Dynamic light scattering and transmission electron microscopy of the DNA aptamer-decorated artificial viral capsid showed the formation of spherical assemblies with a diameter of approximately 50-150 nm. The artificial viral capsid was selectively internalized into the Burkitt lymphoma cell line, Daudi, and doxorubicin complexed with the capsid selectively killed Daudi cells. |
| Volume | 11(26) |
| Pages | 6053-6059 |
| Published | 2023-7-5 |
| DOI | 10.1039/d3tb00169e |
| PMID | 37310262 |
| MeSH | Aptamers, Nucleotide* Burkitt Lymphoma* / drug therapy Capsid Doxorubicin / pharmacology Humans Peptides |
| IF | 5.344 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 13 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | HeLa(RCB0007) |