| RRC ID |
78828
|
| 著者 |
Sasayama Y, Mamiya T, Qi J, Shibata T, Uchida K, Nabeshima T, Ojika M.
|
| タイトル |
Neuritogenic steroid glycosides from crown-of-thorns starfish: Possible involvement of p38 mitogen-activated protein kinase and attenuation of cognitive impairment in senescence-accelerated mice (SAMP8) by peripheral administration.
|
| ジャーナル |
Bioorg Med Chem
|
| Abstract |
Novel steroid glycosides, acanthasterosides A1, B1, and B3, have been isolated from the crown-of-thorns starfish Acanthaster planci. Acanthasterosides B1 and B3 having two separated xyloses induced neurite outgrowth as like as nerve growth factor (NGF) in the rat pheochromocytoma cell line PC12, whereas acanthasteroside A1, having one xylose, did not induce neurite outgrowth. The acanthasteroside B3 induced neuritogenesis via the significant activation of p38 mitogen-activated protein kinase after the activation of the small G-protein Cdc42 rather than via Ras-MEK-ERK pathway that is predominantly activated by NGF. Following subcutaneous administration, acanthasteroside B3 attenuated cognitive impairment of senescence-accelerated mice (SAMP8) in two different cognitive tests. Liquid chromatography-mass spectrometry-assisted quantitative analysis demonstrated that acanthasteroside B3 could be transported into the brain via the circulatory system in mice. Thus, acanthasteroside B3 (and possibly B1) are a novel class of potential drug candidates for neurodegenerative diseases.
|
| 巻・号 |
78
|
| ページ |
117144
|
| 公開日 |
2023-1-15
|
| DOI |
10.1016/j.bmc.2022.117144
|
| PII |
S0968-0896(22)00537-5
|
| PMID |
36577328
|
| MeSH |
Animals
Cognitive Dysfunction* / metabolism
Mice
Mitogen-Activated Protein Kinase 14* / metabolism
Nerve Growth Factor / metabolism
Nerve Growth Factor / pharmacology
Neurites / metabolism
PC12 Cells
Rats
Starfish / metabolism
Steroids
p38 Mitogen-Activated Protein Kinases / metabolism
|
| リソース情報 |
| ヒト・動物細胞 |
PC-12(RCB0009) |
