| RRC ID |
78840
|
| 著者 |
Yi B, Tanaka YL, Cornish D, Kosako H, Butlertanaka EP, Sengupta P, Lippincott-Schwartz J, Hultquist JF, Saito A, Yoshimura SH.
|
| タイトル |
Host ZCCHC3 blocks HIV-1 infection and production through a dual mechanism.
|
| ジャーナル |
iScience
|
| Abstract |
Most mammalian cells prevent viral infection and proliferation by expressing various restriction factors and sensors that activate the immune system. Several host restriction factors that inhibit human immunodeficiency virus type 1 (HIV-1) have been identified, but most of them are antagonized by viral proteins. Here, we describe CCHC-type zinc-finger-containing protein 3 (ZCCHC3) as a novel HIV-1 restriction factor that suppresses the production of HIV-1 and other retroviruses, but does not appear to be directly antagonized by viral proteins. It acts by binding to Gag nucleocapsid (GagNC) via zinc-finger motifs, which inhibits viral genome recruitment and results in genome-deficient virion production. ZCCHC3 also binds to the long terminal repeat on the viral genome via the middle-folded domain, sequestering the viral genome to P-bodies, which leads to decreased viral replication and production. This distinct, dual-acting antiviral mechanism makes upregulation of ZCCHC3 a novel potential therapeutic strategy.
|
| 巻・号 |
27(3)
|
| ページ |
109107
|
| 公開日 |
2024-3-15
|
| DOI |
10.1016/j.isci.2024.109107
|
| PII |
S2589-0042(24)00328-6
|
| PMID |
38384847
|
| PMC |
PMC10879702
|
| リソース情報 |
| ヒト・動物細胞 |
COS-7(RCB0539) |
