論文 - 詳細
| RRC ID | 78856 |
|---|---|
| 著者 | Uemura K, Nobori H, Sato A, Toba S, Kusakabe S, Sasaki M, Tabata K, Matsuno K, Maeda N, Ito S, Tanaka M, Anraku Y, Kita S, Ishii M, Kanamitsu K, Orba Y, Matsuura Y, Hall WW, Sawa H, Kida H, Matsuda A, Maenaka K. |
| タイトル | 2-thiouridine is a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are causing significant morbidity and mortality worldwide. Furthermore, over 1 million cases of newly emerging or re-emerging viral infections, specifically dengue virus (DENV), are known to occur annually. Because no virus-specific and fully effective treatments against these or many other viruses have been approved, there is an urgent need for novel, effective therapeutic agents. Here, we identified 2-thiouridine (s2U) as a broad-spectrum antiviral ribonucleoside analogue that exhibited antiviral activity against several positive-sense single-stranded RNA (ssRNA+) viruses, such as DENV, SARS-CoV-2, and its variants of concern, including the currently circulating Omicron subvariants. s2U inhibits RNA synthesis catalyzed by viral RNA-dependent RNA polymerase, thereby reducing viral RNA replication, which improved the survival rate of mice infected with DENV2 or SARS-CoV-2 in our animal models. Our findings demonstrate that s2U is a potential broad-spectrum antiviral agent not only against DENV and SARS-CoV-2 but other ssRNA+ viruses. |
| 巻・号 | 120(42) |
| ページ | e2304139120 |
| 公開日 | 2023-10-17 |
| DOI | 10.1073/pnas.2304139120 |
| PMID | 37831739 |
| PMC | PMC10589713 |
| MeSH | Animals Antiviral Agents / pharmacology Mice Nucleosides* / pharmacology Positive-Strand RNA Viruses* RNA SARS-CoV-2 Virus Replication |
| IF | 9.412 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 337 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MA104(RCB0994) 293T(RCB2202) HuH-7(RCB1942) A549(RCB0098) |