論文 - 詳細
| RRC ID | 78882 |
|---|---|
| 著者 | Kamoshida S, Watanabe K, Suzuki M, Mizutani Y, Sakamoto K, Sugimoto Y, Oka T, Fukushima M, Tsutsumi Y. |
| タイトル | Expression of cancer cachexia-related factors in human cancer xenografts: an immunohistochemical analysis. |
| ジャーナル | Biomed Res |
| Abstract |
We immunohistochemically evaluated the involvement of five cancer cachexia-related factors, including leukemia-inhibitory factor (LIF), zinc-alpha2-glycoprotein (ZAG), interleukin 6 (IL-6), proteolysis-inducing factor (PIF) and tumor necrosis factor alpha (TNF alpha) in causing cancer cachexia. Twenty-six xenografts implanted into mice were examined for the expression of the cancer cachexia-related factors, in relation to the body weight loss of the hosts. Five xenografts were categorized in the cachectic group, and the remaining 21 xenografts belonged to the non-cachectic group. LIF was extensively expressed in both the cachectic and non-cachectic groups. ZAG and IL-6 were expressed in one of the cachectic and some non-cachectic xenografts. PIF and TNF alpha were detected in one and two non-cachectic xenografts, respectively, but in none of the cachectic ones. Any of five factors examined were not conclusive for causing cancer cachexia in the murine xenograft model. Further analysis is needed in order to elucidate the mechanisms responsible for cancer cachexia. |
| 巻・号 | 27(6) |
| ページ | 275-81 |
| 公開日 | 2006-12-1 |
| DOI | 10.2220/biomedres.27.275 |
| PII | JST.JSTAGE/biomedres/27.275 |
| PMID | 17213683 |
| MeSH | Animals Cachexia / etiology Cachexia / metabolism* Immunohistochemistry Interleukin-6 / metabolism* Leukemia Inhibitory Factor / metabolism* Male Mice Mice, Nude Neoplasm Transplantation Neoplasms / complications Neoplasms / metabolism* Proteoglycans / metabolism* Seminal Plasma Proteins / metabolism* Transplantation, Heterologous Tumor Necrosis Factor-alpha / metabolism* Zn-Alpha-2-Glycoprotein |
| IF | 1.429 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | Lu-134 |