論文 - 詳細
| RRC ID | 78884 |
|---|---|
| 著者 | Miyake K, Li F, Tezuka Y, Awale S, Kadota S. |
| タイトル | Cytotoxic activity of quassinoids from Eurycoma longifolia. |
| ジャーナル | Nat Prod Commun |
| Abstract |
Twenty-four quassinoids isolated from Eurycoma longifolia Jack were investigated for their cytotoxicity against a panel of four different cancer cell lines, which includes three murine cell lines [colon 26-L5 carcinoma (colon 26-L5), B16-BL6 melanoma (B16-BL6), Lewis lung carcinoma (LLC)] and a human lung A549 adenocarcinoma (A549) cell line. Among the tested compounds, eurycomalactone (9) displayed the most potent activity against all the tested cell lines; colon 26-L5 (IC50 = 0.70 microM), B16-BL6 (IC50 = 0.59 microM), LLC (IC50 = 0.78 microM), and A549 (IC50 = 0.73 microM). These activities were comparable to clinically used anticancer agent doxorubicin (colon 26-L5, IC50 = 0.76 microM; B16-BL6, IC50 = 0.86 microM; LLC, IC50 = 0.80 microM; A549, IC50 = 0.66 microM). |
| 巻・号 | 5(7) |
| ページ | 1009-12 |
| 公開日 | 2010-7-1 |
| PMID | 20734929 |
| MeSH | Animals Antineoplastic Agents / chemistry Antineoplastic Agents / pharmacology Cell Line, Tumor Cell Survival / drug effects Drug Screening Assays, Antitumor Eurycoma / chemistry* Humans Mice Molecular Structure Quassins / chemistry* Quassins / pharmacology |
| IF | 0.468 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | A549(RCB0098) |