RRC ID 78922
Author Castañeda-Cortés DC, Rosa IF, Boan AF, Marrone D, Pagliaro N, Oliveira MA, Rodrigues MS, Doretto LB, Silva C, Tavares-Júnior J, Costa DF, Dodds MS, Strobl-Mazzulla PH, Langlois VS, Nóbrega RH, Fernandino JI.
Title Thyroid axis participates in high-temperature-induced male sex reversal through its activation by the stress response.
Journal Cell Mol Life Sci
Abstract Environmental changes alter the sex fate in about 15% of vertebrate orders, mainly in ectotherms such as fish and reptiles. However, the effects of temperature changes on the endocrine and molecular processes controlling gonadal sex determination are not fully understood. Here, we provide evidence that thyroid hormones (THs) act as co-players in heat-induced masculinization through interactions with the stress axis to promote testicular development. We first demonstrated that the thyroid axis (through thyroid-related genes and T3 levels) is highly active in males during the gonadal development in medaka (Oryzias latipes). Similarly, T3 treatments promoted female-to-male sex reversal in XX embryos. Subsequently, embryonic exposure to temperature-induced stress up-regulated the genes related to the thyroid and stress axes with a final increase in T3 levels. In this context, we show that blocking the stress axis response by the loss of function of the corticotropin-releasing hormone receptors suppresses thyroid-stimulating hormone expression, therefore, heat-induced activation of the thyroid axis. Thus, our data showed that early activation of the stress axis and, in consequence, the TH axis, too, leaves us with that both being important endocrine players in inducing female-to-male reversal, which can help predict possible upcoming physiological impacts of global warming on fish populations.
Volume 80(9)
Pages 253
Published 2023-8-17
DOI 10.1007/s00018-023-04913-6
PII 10.1007/s00018-023-04913-6
PMID 37589787
MeSH Animals Female Gonads Hot Temperature* Male Plant Leaves Temperature Thyroid Gland*
Medaka HNI-II (Strain ID: MT835).