論文 - 詳細
| RRC ID | 78959 |
|---|---|
| 著者 | Yasuda K, Watanabe TM, Kang MG, Seo JK, Rhee HW, Tate SI. |
| タイトル | Valosin-containing protein regulates the stability of fused in sarcoma granules in cells by changing ATP concentrations. |
| ジャーナル | FEBS Lett |
| Abstract |
Fused in sarcoma (FUS), a DNA/RNA-binding protein, undergoes liquid-liquid phase separation to form granules in cells. Aberrant FUS granulation is associated with neurodegenerative diseases, including amyotrophic lateral sclerosis and frontotemporal lobar degeneration. We found that FUS granules contain a multifunctional AAA ATPase, valosin-containing protein (VCP), which is known as a key regulator of protein degradation. FUS granule stability depends on ATP concentrations in cells. VCP ATPase changes the FUS granule stability time-dependently by consuming ATP to reduce its concentrations in the granules: VCPs in de novo FUS granules stabilize the granules, while long-lasting VCP colocalization destabilizes the granules. The proteolysis-promoting function of VCP may subsequently dissolve the unstabilized granules. We propose that VCP colocalized to the FUS granules acts as a timer to limit the residence time of the granules in cells. |
| 巻・号 | 596(11) |
| ページ | 1412-1423 |
| 公開日 | 2022-6-1 |
| DOI | 10.1002/1873-3468.14353 |
| PMID | 35445401 |
| MeSH | Adenosine Triphosphate Amyotrophic Lateral Sclerosis* / metabolism Frontotemporal Lobar Degeneration* / metabolism Humans RNA-Binding Protein FUS / genetics RNA-Binding Protein FUS / metabolism Sarcoma* Valosin Containing Protein / genetics Valosin Containing Protein / metabolism |
| IF | 3.057 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | NIH/3T3(RCB2767) |