| RRC ID |
78960
|
| 著者 |
Nagai K, Akimoto J, Fukami S, Saito Y, Ogawa E, Takanashi M, Kuroda M, Kohno M.
|
| タイトル |
Efficacy of interstitial photodynamic therapy using talaporfin sodium and a semiconductor laser for a mouse allograft glioma model.
|
| ジャーナル |
Sci Rep
|
| Abstract |
To investigate the therapeutic potential of photodynamic therapy (PDT) for malignant gliomas arising in unresectable sites, we investigated the effect of tumor tissue damage by interstitial PDT (i-PDT) using talaporfin sodium (TPS) in a mouse glioma model in which C6 glioma cells were implanted subcutaneously. A kinetic study of TPS demonstrated that a dose of 10 mg/kg and 90 min after administration was appropriate dose and timing for i-PDT. Performing i-PDT using a small-diameter plastic optical fiber demonstrated that an irradiation energy density of 100 J/cm2 or higher was required to achieve therapeutic effects over the entire tumor tissue. The tissue damage induced apoptosis in the area close to the light source, whereas vascular effects, such as fibrin thrombus formation occurred in the area slightly distant from the light source. Furthermore, when irradiating at the same energy density, irradiation at a lower power density for a longer period of time was more effective than irradiation at a higher power density for a shorter time. When performing i-PDT, it is important to consider the rate of delivery of the irradiation light into the tumor tissue and to set irradiation conditions that achieve an optimal balance between cytotoxic and vascular effects.
|
| 巻・号 |
14(1)
|
| ページ |
9137
|
| 公開日 |
2024-4-21
|
| DOI |
10.1038/s41598-024-59955-y
|
| PII |
10.1038/s41598-024-59955-y
|
| PMID |
38644422
|
| PMC |
PMC11033255
|
| MeSH |
Allografts
Animals
Apoptosis / drug effects
Cell Line, Tumor
Disease Models, Animal
Glioma* / drug therapy
Glioma* / pathology
Lasers, Semiconductor* / therapeutic use
Male
Mice
Photochemotherapy* / methods
Photosensitizing Agents* / pharmacology
Photosensitizing Agents* / therapeutic use
Porphyrins* / pharmacology
Porphyrins* / therapeutic use
|
| リソース情報 |
| ヒト・動物細胞 |
C6(RCB2854) |
