Reference - Detail
| RRC ID | 78975 |
|---|---|
| Author | Mitchell A. Jeffs, Rachel A. V. Gray, Prameet M. Sheth, Christopher T. Lohans |
| Title | Development of a whole-cell biosensor for β-lactamase inhibitor discovery |
| Journal | Chemical Communications |
| Abstract |
We developed a whole-cell biosensor that quantifies β-lactamase inhibition in a cellular context. This assay accounts for factors such as membrane permeability and can be used to identify novel β-lactamase inhibitors. |
| Volume | 59 |
| Pages | 12707-12710 |
| Published | 2023-1-1 |
| DOI | 10.1039/d3cc03583b |
| PMID | 37801331 |
| MeSH | Anti-Bacterial Agents* / pharmacology Anti-Bacterial Agents* / therapeutic use Bacteria beta-Lactamase Inhibitors* / pharmacology beta-Lactamases beta-Lactams / pharmacology |
| Resource | |
| Prokaryotes E. coli | |