| RRC ID |
78984
|
| 著者 |
Beata Kruszewska-Naczk, Mariusz Grinholc, Krzysztof Waleron, Julia Elisabeth Bandow, Aleksandra Rapacka-Zdończyk
|
| タイトル |
Can antimicrobial blue light contribute to resistance development? Genome-wide analysis revealed aBL-protective genes in
Escherichia coli
|
| ジャーナル |
Microbiology Spectrum
|
| Abstract |
ABSTRACT
Antimicrobial blue light (aBL) is a promising non-antibiotic approach to fighting multidrug-resistant bacteria. However, the complete mechanism of aBL action is not fully understood yet. This study contributes to a better understanding that the response to aBL depends on many factors and that it is hardly possible to identify a predominant mechanism underlying microbial sensitivity to photoinactivation. The results of this study provide insights into genetic changes that may lead to bacterial survival at higher aBL doses, giving rise to aBL-resistant strains. To our best knowledge, this is the first study concerning genome-wide mutant testing of aBL. We managed to identify 64 single-gene mutants that lacked certain protective genes expressing aBL-increased sensitivity.
IMPORTANCE
Increasing antibiotic resistance and the lack of new antibiotic-like compounds to combat bacterial resistance are significant problems of modern medicine. The development of new alternative therapeutic strategies is extremely important. Antimicrobial blue light (aBL) is an innovative approach to combat multidrug-resistant microorganisms. aBL has a multitarget mode of action; however, the full mechanism of aBL antibacterial action requires further investigation. In addition, the potential risk of resistance development to this treatment should be considered.
|
| 巻・号 |
12
|
| 公開日 |
2024-1-11
|
| DOI |
10.1128/spectrum.02490-23
|
| PMID |
38063383
|
| PMC |
PMC10782963
|
| MeSH |
Anti-Bacterial Agents / pharmacology
Anti-Infective Agents* / pharmacology
Blue Light
Drug Resistance, Microbial
Escherichia coli* / genetics
Microbial Sensitivity Tests
|
| リソース情報 |
| 原核生物(大腸菌) |
ME9062
Keio collection
ASKA library |
