論文 - 詳細
| RRC ID | 79003 |
|---|---|
| 著者 | Pino-Jiménez B, Giannios P, Casanova J. |
| タイトル | Polyploidy-associated autophagy promotes larval tracheal histolysis at Drosophila metamorphosis. |
| ジャーナル | Autophagy |
| Abstract |
Polyploidy is an extended phenomenon in biology. However, its physiological significance and whether it defines specific cell behaviors is not well understood. Here we study its connection to macroautophagy/autophagy, using the larval respiratory system of Drosophila as a model. This system comprises cells with the same function yet with notably different ploidy status, namely diploid progenitors and their polyploid larval counterparts, the latter destined to die during metamorphosis. We identified an association between polyploidy and autophagy and found that higher endoreplication status correlates with elevated autophagy. Finally, we report that tissue histolysis in the trachea during Drosophila metamorphosis is mediated by autophagy, which triggers the apoptosis of polyploid cells.Abbreviations: APF: after pupa formation; Atg: autophagy related; btl: breathless; CycE: Cyclin E; DT: dorsal trunk; fzr: fizzy-related; L3: larval stage 3; PBS: phosphate-buffered saline; RI: RNAi; Tr: tracheal metamere; yki: yorkie. |
| 巻・号 | 19(11) |
| ページ | 2972-2981 |
| 公開日 | 2023-11-1 |
| DOI | 10.1080/15548627.2023.2231828 |
| PMID | 37424089 |
| PMC | PMC10549192 |
| MeSH | Animals Autophagy Drosophila* Drosophila Proteins* / genetics Drosophila melanogaster Larva Polyploidy Trachea |
| IF | 9.77 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 17 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.2 |
| リソース情報 | |
| ショウジョウバエ | DGRC#109128 |