論文 - 詳細
| RRC ID | 79017 |
|---|---|
| 著者 | Trombley S, Powell J, Guttipatti P, Matamoros A, Lin X, O'Harrow T, Steinschaden T, Miles L, Wang Q, Wang S, Qiu J, Li Q, Li F, Song Y. |
| タイトル | Glia instruct axon regeneration via a ternary modulation of neuronal calcium channels in Drosophila. |
| ジャーナル | Nat Commun |
| Abstract |
A neuron's regenerative capacity is governed by its intrinsic and extrinsic environment. Both peripheral and central neurons exhibit cell-type-dependent axon regeneration, but the underlying mechanism is unclear. Glia provide a milieu essential for regeneration. However, the routes of glia-neuron signaling remain underexplored. Here, we show that regeneration specificity is determined by the axotomy-induced Ca2+ transients only in the fly regenerative neurons, which is mediated by L-type calcium channels, constituting the core intrinsic machinery. Peripheral glia regulate axon regeneration via a three-layered and balanced modulation. Glia-derived tumor necrosis factor acts through its neuronal receptor to maintain calcium channel expression after injury. Glia sustain calcium channel opening by enhancing membrane hyperpolarization via the inwardly-rectifying potassium channel (Irk1). Glia also release adenosine which signals through neuronal adenosine receptor (AdoR) to activate HCN channels (Ih) and dampen Ca2+ transients. Together, we identify a multifaceted glia-neuron coupling which can be hijacked to promote neural repair. |
| 巻・号 | 14(1) |
| ページ | 6490 |
| 公開日 | 2023-10-14 |
| DOI | 10.1038/s41467-023-42306-2 |
| PII | 10.1038/s41467-023-42306-2 |
| PMID | 37838791 |
| PMC | PMC10576831 |
| MeSH | Animals Axons* / metabolism Calcium / metabolism Calcium Channels* / metabolism Drosophila / metabolism Nerve Regeneration Neuroglia / metabolism Neurons / metabolism |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#113604 DGRC#140097 |