論文 - 詳細
| RRC ID | 79024 |
|---|---|
| 著者 | Tsuboi A, Fujimoto K, Kondo T. |
| タイトル | Spatiotemporal remodeling of extracellular matrix orients epithelial sheet folding. |
| ジャーナル | Sci Adv |
| Abstract |
Biological systems are inherently noisy; however, they produce highly stereotyped tissue morphology. Drosophila pupal wings show a highly stereotypic folding through uniform expansion and subsequent buckling of wing epithelium within a surrounding cuticle sac. The folding pattern produced by buckling is generally stochastic; it is thus unclear how buckling leads to stereotypic tissue folding of the wings. We found that the extracellular matrix (ECM) protein, Dumpy, guides the position and direction of buckling-induced folds. Dumpy anchors the wing epithelium to the overlying cuticle at specific tissue positions. Tissue-wide alterations of Dumpy deposition and degradation yielded different buckling patterns. In summary, we propose that spatiotemporal ECM remodeling shapes stereotyped tissue folding through dynamic interactions between the epithelium and its external structures. |
| 巻・号 | 9(35) |
| ページ | eadh2154 |
| 公開日 | 2023-9-1 |
| DOI | 10.1126/sciadv.adh2154 |
| PMID | 37656799 |
| PMC | PMC10854429 |
| MeSH | Animals Drosophila Epithelium Extracellular Matrix* Extracellular Matrix Proteins* Stereotyped Behavior |
| IF | 13.117 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 28 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#115238 DGRC#106798 |