RRC ID 79025
Author Chen CC, Lin HW, Feng KL, Tseng DW, de Belle JS, Chiang AS.
Title A subset of cholinergic mushroom body neurons blocks long-term memory formation in Drosophila.
Journal Cell Rep
Abstract Long-term memory (LTM) requires learning-induced synthesis of new proteins allocated to specific neurons and synapses in a neural circuit. Not all learned information, however, becomes permanent memory. How the brain gates relevant information into LTM remains unclear. In Drosophila adults, weak learning after a single training session in an olfactory aversive task typically does not induce protein-synthesis-dependent LTM. Instead, strong learning after multiple spaced training sessions is required. Here, we report that pre-synaptic active-zone protein synthesis and cholinergic signaling from the early α/β subset of mushroom body (MB) neurons produce a downstream inhibitory effect on LTM formation. When we eliminated inhibitory signaling from these neurons, weak learning was then sufficient to form LTM. This bidirectional circuit mechanism modulates the transition between distinct memory phase functions in different subpopulations of MB neurons in the olfactory memory circuit.
Volume 42(8)
Pages 112974
Published 2023-8-29
DOI 10.1016/j.celrep.2023.112974
PII S2211-1247(23)00985-3
PMID 37590142
Drosophila DGRC#103496