論文 - 詳細
| RRC ID | 79034 |
|---|---|
| 著者 | Kurogi Y, Imura E, Mizuno Y, Hoshino R, Nouzova M, Matsuyama S, Mizoguchi A, Kondo S, Tanimoto H, Noriega FG, Niwa R. |
| タイトル | Female reproductive dormancy in Drosophila is regulated by DH31-producing neurons projecting into the corpus allatum. |
| ジャーナル | Development |
| Abstract |
Female insects can enter reproductive diapause, a state of suspended egg development, to conserve energy under adverse environments. In many insects, including the fruit fly, Drosophila melanogaster, reproductive diapause, also frequently called reproductive dormancy, is induced under low-temperature and short-day conditions by the downregulation of juvenile hormone (JH) biosynthesis in the corpus allatum (CA). In this study, we demonstrate that neuropeptide Diuretic hormone 31 (DH31) produced by brain neurons that project into the CA plays an essential role in regulating reproductive dormancy by suppressing JH biosynthesis in adult D. melanogaster. The CA expresses the gene encoding the DH31 receptor, which is required for DH31-triggered elevation of intracellular cAMP in the CA. Knocking down Dh31 in these CA-projecting neurons or DH31 receptor in the CA suppresses the decrease of JH titer, normally observed under dormancy-inducing conditions, leading to abnormal yolk accumulation in the ovaries. Our findings provide the first molecular genetic evidence demonstrating that CA-projecting peptidergic neurons play an essential role in regulating reproductive dormancy by suppressing JH biosynthesis. |
| 巻・号 | 150(10) |
| 公開日 | 2023-5-15 |
| DOI | 10.1242/dev.201186 |
| PII | 310536 |
| PMID | 37218457 |
| PMC | PMC10233717 |
| MeSH | Animals Corpora Allata Drosophila Proteins / genetics Drosophila Proteins / physiology Drosophila melanogaster* / genetics Drosophila melanogaster* / physiology Female Insect Hormones* / genetics Insect Hormones* / physiology Juvenile Hormones Neurons Reproduction |
| IF | 5.611 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 28 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#110692 17043R-1 |