RRC ID 79050
Author Suyama R, Cetraro N, Yew JY, Kai T.
Title Microbes control Drosophila germline stem cell increase and egg maturation through hormonal pathways.
Journal Commun Biol
Abstract Reproduction is highly dependent on environmental and physiological factors including nutrition, mating stimuli and microbes. Among these factors, microbes facilitate vital functions for host animals such as nutritional intake, metabolic regulation, and enhancing fertility under poor nutrition conditions. However, detailed molecular mechanisms by which microbes control germline maturation, leading to reproduction, remain largely unknown. In this study, we show that environmental microbes exert a beneficial effect on Drosophila oogenesis by promoting germline stem cell (GSC) proliferation and subsequent egg maturation via acceleration of ovarian cell division and suppression of apoptosis. Moreover, insulin-related signaling is not required; rather, the ecdysone pathway is necessary for microbe-induced increase of GSCs and promotion of egg maturation, while juvenile hormone contributes only to increasing GSC numbers, suggesting that hormonal pathways are activated at different stages of oogenesis. Our findings reveal that environmental microbes can enhance host reproductivity by modulating host hormone release and promoting oogenesis.
Volume 6(1)
Pages 1287
Published 2023-12-20
DOI 10.1038/s42003-023-05660-x
PII 10.1038/s42003-023-05660-x
PMID 38123715
PMC PMC10733356
MeSH Animals Drosophila* / metabolism Female Germ Cells / metabolism Oogenesis* / physiology Ovary Stem Cells / metabolism