| RRC ID |
79067
|
| 著者 |
Fujii K, Iwata I, Takaya A, Ishibashi M, Hara Y.
|
| タイトル |
New biflavonoids isolated from Xylia kerrii leaves extract with selective cytotoxicity against MH7A human rheumatoid arthritis synovial fibroblast cells.
|
| ジャーナル |
J Nat Med
|
| Abstract |
Three new biflavonoids (1-3) and two known flavonoids (4, 5) were isolated from Xylia kerrii collected in Thailand. Compounds 1-5 showed selective cytotoxicity against the rheumatoid fibroblast-like synovial MH7A cell line, and these compounds showed weak cytotoxicity against the human lung synovial fibroblast WI-38 VA13 sub 2 RA cell line. Notably, compound 1 was highly selective toward MH7A cells with an IC50 value of 6.9 μM, whereas the IC50 value for WI-38 VA13 sub 2 RA cells was > 100 μM. The western blotting analysis of MH7A cells treated with compound 1 showed increased CDKN2A /p16INK4A and caspase-8 levels.
|
| 公開日 |
2024-4-9
|
| DOI |
10.1007/s11418-024-01801-6
|
| PII |
10.1007/s11418-024-01801-6
|
| PMID |
38592349
|
| リソース情報 |
| ヒト・動物細胞 |
MH7A(RCB1512) |
