| RRC ID |
79086
|
| Author |
Zaupa M, Nagaraj N, Sylenko A, Baier H, Sawamiphak S, Filosa A.
|
| Title |
The Calmodulin-interacting peptide Pcp4a regulates feeding state-dependent behavioral choice in zebrafish.
|
| Journal |
Neuron
|
| Abstract |
Animals constantly need to judge the valence of an object in their environment: is it potential food or a threat? The brain makes fundamental decisions on the appropriate behavioral strategy by integrating external information from sensory organs and internal signals related to physiological needs. For example, a hungry animal may take more risks than a satiated one when deciding to approach or avoid an object. Using a proteomic profiling approach, we identified the Calmodulin-interacting peptide Pcp4a as a key regulator of foraging-related decisions. Food intake reduced abundance of protein and mRNA of pcp4a via dopamine D2-like receptor-mediated repression of adenylate cyclase. Accordingly, deleting the pcp4a gene made zebrafish larvae more risk averse in a binary decision assay. Strikingly, neurons in the tectum became less responsive to prey-like visual stimuli in pcp4a mutants, thus biasing the behavior toward avoidance. This study pinpoints a molecular mechanism modulating behavioral choice according to internal state.
|
| Volume |
112(7)
|
| Pages |
1150-1164.e6
|
| Published |
2024-4-3
|
| DOI |
10.1016/j.neuron.2024.01.001
|
| PII |
S0896-6273(24)00001-1
|
| PMID |
38295792
|
| MeSH |
Animals
Calmodulin* / metabolism
Feeding Behavior / physiology
Hunger / physiology
Neurons / physiology
Proteomics
Zebrafish* / physiology
|
| IF |
14.415
|
| Resource |
| Zebrafish |
Tg(huC:GVP)
UAS:GFP |
