論文 - 詳細
| RRC ID | 79112 |
|---|---|
| 著者 | Chung J, Newman-Smith E, Kourakis MJ, Miao Y, Borba C, Medina J, Laurent T, Gallean B, Faure E, Smith WC. |
| タイトル | A single oscillating proto-hypothalamic neuron gates taxis behavior in the primitive chordate Ciona. |
| ジャーナル | Curr Biol |
| Abstract |
Ciona larvae display a number of behaviors, including negative phototaxis. In negative phototaxis, the larvae first perform short spontaneous rhythmic casting swims. As larvae are cast in a light field, their photoreceptors are directionally shaded by an associated pigment cell, providing a phototactic cue. This then evokes an extended negative taxis swim. We report here that the larval forebrain of Ciona has a previously uncharacterized single slow-oscillating inhibitory neuron (neuron cor-assBVIN78) that projects to the midbrain, where it targets key interneurons of the phototaxis circuit known as the photoreceptor relay neurons. The anatomical location, gene expression, and oscillation of cor-assBVIN78 suggest homology to oscillating neurons of the vertebrate hypothalamus. Ablation of cor-assBVIN78 results in larvae showing extended phototaxis-like swims, even in the absence of phototactic cues. These results indicate that cor-assBVIN78 has a gating activity on phototaxis by projecting temporally oscillating inhibition to the photoreceptor relay neurons. However, in intact larvae, the frequency of cor-assBVIN78 oscillation does not match that of the rhythmic spontaneous swims, indicating that the troughs in oscillations do not themselves initiate swims but rather that cor-assBVIN78 may modulate the phototaxis circuit by filtering out low-level inputs while restricting them temporally to the troughs in inhibition. |
| 巻・号 | 33(16) |
| ページ | 3360-3370.e4 |
| 公開日 | 2023-8-21 |
| DOI | 10.1016/j.cub.2023.06.080 |
| PII | S0960-9822(23)00866-7 |
| PMID | 37490920 |
| PMC | PMC10528541 |
| MeSH | Animals Ciona* / physiology Ciona intestinalis* Hypothalamus Larva / physiology Neurons / physiology Photoreceptor Cells / physiology |
| IF | 9.601 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| カタユウレイボヤ・(ニッポンウミシダ) | Tg[MiCivGATK]2 |