Reference - Detail
| RRC ID | 79171 |
|---|---|
| Author | Dsilva P, Pai P, Shetty MG, Babitha KS. |
| Title | The role of histone deacetylases in embryonic development. |
| Journal | Mol Reprod Dev |
| Abstract |
The basic units of chromatin are nucleosomes, that are made up of DNA wrapped around histone cores. Histone lysine residue is a common location for posttranslational modifications, with acetylation being the second most prevalent. Histone acetyltransferases (HATs/KATs) and histone deacetylases (HDACs/KDACs) regulate histone acetylation, which is important in gene expression control. HDACs/KDACs regulate gene expressions through the repression of the transcription machinery. HDAC/KDAC isoforms play a major role during various stages of embryo development and neurogenesis. In specific, class I and II HDACs/KDACs are involved in cardiac muscle differentiation and development. An insight into different pathways and genes associated with embryonic development, the effect of HDAC/KDAC activity during the embryonic stem cell differentiation, preimplantation, embryo development, gastrulation, and the role of different HDAC/KDAC inhibitors during the process of embryogenesis is summarized in the present review article. |
| Volume | 90(1) |
| Pages | 14-26 |
| Published | 2023-1-1 |
| DOI | 10.1002/mrd.23659 |
| PMID | 36534913 |
| MeSH | Acetylation Chromatin Embryonic Development Histone Deacetylase Inhibitors / pharmacology Histone Deacetylases* / metabolism Histones* / metabolism |
| IF | 2.823 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 6 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Zebrafish | RIKEN WT |