論文 - 詳細
| RRC ID | 79212 |
|---|---|
| 著者 | Peng D, Zheng L, Liu D, Han C, Wang X, Yang Y, Song L, Zhao M, Wei Y, Li J, Ye X, Wei Y, Feng Z, Huang X, Chen M, Gou Y, Xue Y, Zhang L. |
| タイトル | Large-language models facilitate discovery of the molecular signatures regulating sleep and activity. |
| ジャーナル | Nat Commun |
| Abstract |
Sleep, locomotor and social activities are essential animal behaviors, but their reciprocal relationships and underlying mechanisms remain poorly understood. Here, we elicit information from a cutting-edge large-language model (LLM), generative pre-trained transformer (GPT) 3.5, which interprets 10.2-13.8% of Drosophila genes known to regulate the 3 behaviors. We develop an instrument for simultaneous video tracking of multiple moving objects, and conduct a genome-wide screen. We have identified 758 fly genes that regulate sleep and activities, including mre11 which regulates sleep only in the presence of conspecifics, and NELF-B which regulates sleep regardless of whether conspecifics are present. Based on LLM-reasoning, an educated signal web is modeled for understanding of potential relationships between its components, presenting comprehensive molecular signatures that control sleep, locomotor and social activities. This LLM-aided strategy may also be helpful for addressing other complex scientific questions. |
| 巻・号 | 15(1) |
| ページ | 3685 |
| 公開日 | 2024-5-1 |
| DOI | 10.1038/s41467-024-48005-w |
| PII | 10.1038/s41467-024-48005-w |
| PMID | 38693116 |
| PMC | PMC11063160 |
| MeSH | Animals Behavior, Animal* / physiology Drosophila Proteins / genetics Drosophila Proteins / metabolism Drosophila melanogaster* / genetics Drosophila melanogaster* / physiology Locomotion* / genetics Locomotion* / physiology Male Sleep* / genetics Sleep* / physiology Social Behavior |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 105 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 11861R-2 |