論文 - 詳細
| RRC ID | 79326 |
|---|---|
| 著者 | Li N, Wu JL, Hasegawa T, Sakai J, Bai LM, Wang LY, Kakuta S, Furuya Y, Ogura H, Kataoka T, Tomida A, Tsuruo T, Ando M. |
| タイトル | Bioactive polyketides from Peperomia duclouxii. |
| ジャーナル | J Nat Prod |
| Abstract |
Four new compounds (1-4) were isolated along with 16 known compounds from whole plants of Peperomia duclouxii. The new structures were elucidated as 4-hydroxy-2-[(3,4-methylenedioxyphenyl)nonanoyl]cyclohexane-1,3-dione (1), 4-hydroxy-2-[(3,4-methylenedioxyphenyl)undecanoyl]cyclohexane-1,3-dione (2), 4-hydroxy-2-[(3,4-methylenedioxyphenyl)tridecanoyl]cyclohexane-1,3-dione (3), and 2-[(3,4-methylenedioxyphenyl)dodecyl]-4-hydroxy-2,3,4,6,7,8-hexahydro-2H-1-benzopyran-5-one (4), by analysis of their spectroscopic data. The known polyketides, surinone A and oleiferinone, showed cell growth inhibitory activity against the WI-38, VA-13, and HepG2 cell lines with IC50 values that ranged from 4.4 to 9.6 microg/mL. The known sesquiterpenoid, sinugibberodiol, showed a more potent effect on calcein accumulation than verapamil at 2.5 and 25 microg/mL. Compounds 3 and 4, surinone A, and oleiferinone showed moderate to weak inhibitory activity on the induction of the intercellular adhesion molecule-1 (ICAM-1) in the presence of IL-1alpha or TNF-alpha. |
| 巻・号 | 70(6) |
| ページ | 998-1001 |
| 公開日 | 2007-6-1 |
| DOI | 10.1021/np070089n |
| PMID | 17547458 |
| MeSH | Cyclohexanones / chemistry Cyclohexanones / isolation & purification* Cyclohexanones / pharmacology* Drugs, Chinese Herbal / chemistry Drugs, Chinese Herbal / isolation & purification* Drugs, Chinese Herbal / pharmacology* Female Fluoresceins / pharmacology Humans Inhibitory Concentration 50 Intercellular Adhesion Molecule-1 / drug effects Interleukin-1alpha / metabolism Molecular Structure Peperomia / chemistry* Plants, Medicinal / chemistry* Sesquiterpenes / chemistry Sesquiterpenes / isolation & purification Sesquiterpenes / pharmacology Tumor Cells, Cultured Tumor Necrosis Factor-alpha / metabolism Verapamil / pharmacology |
| IF | 3.782 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | WI-38 VA-13(RCB0251) Hep G2 |