Reference - Detail
| RRC ID | 79329 |
|---|---|
| Author | Wu JL, Li N, Hasegawa T, Sakai J, Kakuta S, Tang W, Oka S, Kiuchi M, Ogura H, Kataoka T, Tomida A, Tsuruo T, Ando M. |
| Title | Bioactive tetrahydrofuran lignans from Peperomia dindygulensis. |
| Journal | J Nat Prod |
| Abstract |
Five new tetrahydrofuran lignans (1-5), accompanied by four known compounds, were isolated from the ethyl acetate extract of Peperomia dindygulensis. Structures were elucidated mainly using 1D NMR, 2D NMR, and mass spectroscopic studies. The relative configurations of 1-5 were determined by NOE correlations. Several of the compounds showed weak growth inhibitory activity against three cell lines (WI-38, VA-13, and HepG2). Compound 5 exhibited stronger MDR (multidrug resistance) reversal activity than verapamil at 2.5 microg/mL in a cellular calcein accumulation assay. Compounds 4 and 5 showed weak inhibitory activity against induction of the intercellular adhesion molecule-1 (ICAM-1) in anti-inflammatory activity experiments. |
| Volume | 68(11) |
| Pages | 1656-60 |
| Published | 2005-11-1 |
| DOI | 10.1021/np050283e |
| PMID | 16309318 |
| MeSH | Anti-Inflammatory Agents, Non-Steroidal / chemistry Anti-Inflammatory Agents, Non-Steroidal / isolation & purification* Anti-Inflammatory Agents, Non-Steroidal / pharmacology Antineoplastic Agents, Phytogenic / chemistry Antineoplastic Agents, Phytogenic / isolation & purification* Antineoplastic Agents, Phytogenic / pharmacology Drug Screening Assays, Antitumor Drugs, Chinese Herbal / chemistry Drugs, Chinese Herbal / isolation & purification* Drugs, Chinese Herbal / pharmacology Furans / chemistry Furans / isolation & purification* Furans / pharmacology Humans Intercellular Adhesion Molecule-1 / biosynthesis Intercellular Adhesion Molecule-1 / drug effects Lignans / chemistry Lignans / isolation & purification* Lignans / pharmacology Molecular Structure Nuclear Magnetic Resonance, Biomolecular Peperomia / chemistry* Plants, Medicinal / chemistry* Tumor Cells, Cultured |
| IF | 3.782 |
| Resource | |
| Human and Animal Cells | WI-38 VA-13(RCB0251) Hep G2 |