Reference - Detail
| RRC ID | 79338 |
|---|---|
| Author | Wu JL, Li N, Hasegawa T, Sakai J, Mitsui T, Ogura H, Kataoka T, Oka S, Kiuchi M, Tomida A, Turuo T, Li M, Tang W, Ando M. |
| Title | Bioactive secolignans from Peperomia dindygulensis. |
| Journal | J Nat Prod |
| Abstract |
Thirteen secolignans, including eight new ones (1-8), were isolated from the EtOAc extract of Peperomia dindygulensis. The structures were mainly elucidated by 1D and 2D NMR and MS experiments, the relative configurations were determined by NOE correlations, and the absolute configurations were established by the optical rotations and CD spectra. Cytotoxicity and MDR (multidrug resistance) reversal activity of the isolated compounds were examined. Compounds 6 and 7, peperomins B (10) and E (12), showed moderate to strong growth inhibitory activity against a malignant lung tumor cell (VA-13) with IC(50) values of 15.2, 13.5, 13.9, and 1.93 microM, respectively, and also inhibited the growth of a normal lung fibroblast cell (WI-38) at the same levels. Compound 7 and peperomin E (12) exhibited inhibitory activity against a liver tumor cell (HepG2) with IC(50) values of 22.3 and 12.1 microM. Compounds 5 and 7 and peperomins A, B, C, and E (9-12) enhanced calcein accumulation in MDR 2780 cells at 25 microg/mL. Compounds 2, 3, 7, and peperomin E (12) showed inhibitory activity on induction of the intercellular adhesion molecule-1 (ICAM-1). |
| Volume | 69(5) |
| Pages | 790-4 |
| Published | 2006-5-1 |
| DOI | 10.1021/np0600447 |
| PMID | 16724842 |
| MeSH | Antineoplastic Agents, Phytogenic / chemistry Antineoplastic Agents, Phytogenic / isolation & purification Antineoplastic Agents, Phytogenic / pharmacology Drug Resistance, Multiple Drug Screening Assays, Antitumor Drugs, Chinese Herbal* / chemistry Drugs, Chinese Herbal* / isolation & purification Drugs, Chinese Herbal* / pharmacology Intercellular Adhesion Molecule-1 / metabolism Lignans* / chemistry Lignans* / isolation & purification Lignans* / pharmacology Molecular Structure Peperomia / chemistry* Plants, Medicinal / chemistry* |
| IF | 3.782 |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 5 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | WI-38 VA-13(RCB0251) Hep G2 |