| RRC ID |
79401
|
| Author |
Wu X, Zhou L, Ye C, Zha Z, Li C, Feng C, Zhang Y, Jin Q, Pan J.
|
| Title |
Destruction of self-derived PAMP via T3SS2 effector VopY to subvert PAMP-triggered immunity mediates Vibrio parahaemolyticus pathogenicity.
|
| Journal |
Cell Rep
|
| Abstract |
Cyclic di-guanosine monophosphate (c-di-GMP) is a unique bacterial second messenger but is hijacked by host cells during bacterial infection as a pathogen-associated molecular pattern (PAMP) to trigger STING-dependent immune responses. Here, we show that upon infection, VopY, an effector of Vibrio parahaemolyticus, is injected into host cells by type III secretion system 2 (T3SS2), a secretion system unique to its pathogenic strains and indispensable for enterotoxicity. VopY is an EAL-domain-containing phosphodiesterase and is capable of hydrolyzing c-di-GMP. VopY expression in host cells prevents the activation of STING and STING-dependent downstream signaling triggered by c-di-GMP and, consequently, suppresses type I interferon immune responses. The presence of VopY in V. parahaemolyticus enables it to cause both T3SS2-dependent enterotoxicity and cytotoxicity. These findings uncover the destruction of self-derived PAMPs by injecting specific effectors to suppress PAMP-triggered immune responses as a unique strategy for bacterial pathogens to subvert immunity and cause disease.
|
| Volume |
42(10)
|
| Pages |
113261
|
| Published |
2023-10-31
|
| DOI |
10.1016/j.celrep.2023.113261
|
| PII |
S2211-1247(23)01273-1
|
| PMID |
37847589
|
| MeSH |
Bacterial Proteins / metabolism
Innate Immunity Recognition
Type III Secretion Systems / metabolism
Vibrio parahaemolyticus* / metabolism
Virulence
|
| IF |
8.109
|
| Resource |
| Pathogenic bacteria |
JNBP_30766 |
