論文 - 詳細
| RRC ID | 79420 |
|---|---|
| 著者 | Jewel C De Padua, Emi Fukushima-Sakuno, Kotomi Ueno, Thomas Edison E dela Cruz, Atsushi Ishihara |
| タイトル | Isolation, structure elucidation, and biological activities of sesquiterpenes and phthalides from two edible mushrooms Pleurotus species |
| ジャーナル | Bioscience, Biotechnology, and Biochemistry |
| Abstract |
ABSTRACT
Antimicrobial compounds were purified from culture filtrates from 2 edible Pleurotus species. Using a bioassay-guided fractionation of the culture filtrate extracts, 3 compounds (1-3) were obtained from Pleurotus ostreatus, and another compound (4) was obtained from Pleurotus pulmonarius. Spectroscopic analysis revealed that 1-3 was identified as 5,7-dimethoxyphthalide, 4,6-dimethoxyphthalide, and cheimonophyllon E, respectively, while 4 were identified as pleuroton A. The minimum inhibitory concentration and minimum bactericidal concentration of these compounds were determined against 6 pathogenic bacterial species, Enterococcus faecalis, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter cloacae. Compounds 2 and 4 were inhibitory against all tested bacteria, while 1 and 4 were inhibitory against 3 and 2 species, respectively. In addition, 1-4 inhibited tyrosinase, with IC50 values of 0.10-0.30 mg/mL, and α-glucosidase, with IC50 values of 0.12-0.54 mg/mL. However, their antioxidant capacities were marginal. |
| 巻・号 | 87 |
| ページ | 1429-1441 |
| 公開日 | 2023-11-21 |
| DOI | 10.1093/bbb/zbad126 |
| PMID | 37667536 |
| MeSH | Agaricales* / chemistry Anti-Bacterial Agents / pharmacology Anti-Infective Agents* / pharmacology Bacteria Microbial Sensitivity Tests Pleurotus* Sesquiterpenes* / chemistry |
| IF | 1.516 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| きのこ | TUFC100534 TUFC10665 |