論文 - 詳細
| RRC ID | 79453 |
|---|---|
| 著者 | Akihisa T, Uchiyama E, Kikuchi T, Tokuda H, Suzuki T, Kimura Y. |
| タイトル | Anti-tumor-promoting effects of 25-methoxyporicoic acid A and other triterpene acids from Poria cocos. |
| ジャーナル | J Nat Prod |
| Abstract |
Nine new (1, 3, 5, 8, 12, 13, 15, 17, and 18) and nine known (2, 4, 6, 7, 9-11, 14, and 16) lanostane-type triterpene acids and a known diterpene acid (19) were isolated from the epidermis of the sclerotia of Poria cocos. The structures of the new compounds were established as 16alpha,27-dihydroxydehyrotrametenoic acid (1), 25-hydroxy-3-epitumulosic acid (3), 16alpha,25-dihydroxyeburiconic acid (5), 25-methoxyporicoic acid A (8), 26-hydroxyporicoic acid DM (12), 25-hydroxyporicoic acid C (13), poricoic acid GM (15), poricoic acid HM (17), and 6,7-dehydroporicoic acid H (18), on the basis of spectroscopic methods. On evaluation of the nine new and two of the known compounds, 4 and 19, against the Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells, all of the compounds exhibited inhibitory effects, with IC(50) values in the range 187-348 mol ratio/32 pmol TPA. In addition, compound 8 exhibited an inhibitory effect on skin tumor promotion in an in vivo two-stage carcinogenesis test using 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter. Further, 17 compounds, 1-14, 16, 18, and 19, were evaluated for their cytotoxic activity against two human tumor cell lines, HL60 (leukemia) and CRL1579 (melanoma). |
| 巻・号 | 72(10) |
| ページ | 1786-92 |
| 公開日 | 2009-10-1 |
| DOI | 10.1021/np9003239 |
| PMID | 19746919 |
| MeSH | Anticarcinogenic Agents / chemistry Anticarcinogenic Agents / isolation & purification Anticarcinogenic Agents / pharmacology* Antigens, Viral / drug effects* Drug Screening Assays, Antitumor HL-60 Cells Humans Lanosterol / analogs & derivatives Lanosterol / chemistry Lanosterol / isolation & purification* Lanosterol / pharmacology* Molecular Structure Poria / chemistry* Tetradecanoylphorbol Acetate / pharmacology Triterpenes / chemistry Triterpenes / isolation & purification* Triterpenes / pharmacology* |
| IF | 3.782 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HL60(RCB0041) |