Reference - Detail
| RRC ID | 80041 |
|---|---|
| Author | Li Z, Liu Y, Jones AW, Watanabe Y. |
| Title | Acetylation of Rec8 cohesin complexes regulates reductional chromosome segregation in meiosis. |
| Journal | Life Sci Alliance |
| Abstract |
For establishing sister chromatid cohesion and proper chromosome segregation in mitosis in fission yeast, the acetyltransferase Eso1 plays a key role. Eso1 acetylates cohesin complexes, at two conserved lysine residues K105 and K106 of the cohesin subunit Psm3. Although Eso1 also contributes to reductional chromosome segregation in meiosis, the underlying molecular mechanisms have remained elusive. Here, we purified meiosis-specific Rec8 cohesin complexes localized at centromeres and identified a new acetylation at Psm3-K1013, which largely depends on the meiotic kinetochore factor meikin (Moa1). Our molecular genetic analyses indicate that Psm3-K1013 acetylation cooperates with canonical acetylation at Psm3-K105 and K106, and plays a crucial role in establishing reductional chromosome segregation in meiosis. |
| Volume | 7(6) |
| Published | 2024-6-1 |
| DOI | 10.26508/lsa.202402606 |
| PII | 7/6/e202402606 |
| PMID | 38575358 |
| PMC | PMC10994779 |
| MeSH | Acetylation Cell Cycle Proteins / genetics Cell Cycle Proteins / metabolism Chromosome Segregation / genetics Cohesins Meiosis / genetics Schizosaccharomyces* / genetics Schizosaccharomyces* / metabolism Schizosaccharomyces pombe Proteins* / genetics Schizosaccharomyces pombe Proteins* / metabolism |
| IF | 2.622 |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | X(Twitter) |
| Total number of mentions | 5 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Yeast | |