Reference - Detail
| RRC ID | 80054 |
|---|---|
| Author | Atsushi Noritake, Taihei Ninomiya, Kenta Kobayashi, Masaki Isoda |
| Title | Chemogenetic dissection of a prefrontal-hypothalamic circuit for socially subjective reward valuation in macaques |
| Journal | Nature Communications |
| Abstract |
The value of one’s own reward is affected by the reward of others, serving as a source for envy. However, it is not known which neural circuits mediate such socially subjective value modulation. Here, we chemogenetically dissected the circuit from the medial prefrontal cortex (MPFC) to the lateral hypothalamus (LH) while male macaques were presented with visual stimuli that concurrently signaled the prospects of one’s own and others’ rewards. We found that functional disconnection between the MPFC and LH rendered animals significantly less susceptible to others’ but not one’s own reward prospects. In parallel with this behavioral change, inter-areal coordination, as indexed by coherence and Granger causality, decreased primarily in the delta and theta bands. These findings demonstrate that the MPFC-to-LH circuit plays a crucial role in carrying information about upcoming other-rewards for subjective reward valuation in social contexts. |
| Volume | 14 |
| Published | 2023-7-20 |
| DOI | 10.1038/s41467-023-40143-x |
| PMID | 37474519 |
| PMC | PMC10359292 |
| MeSH | Animals Hypothalamic Area, Lateral Hypothalamus Macaca* Male Prefrontal Cortex Reward* |
| IF | 12.121 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 54 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Japanese macaques | |