| RRC ID |
80204
|
| 著者 |
Oana K, Shimizu K, Takada T, Makino H, Yamazaki M, Katto M, Ando M, Kurakawa T, Oishi K.
|
| タイトル |
Manipulating the growth environment through co-culture to enhance stress tolerance and viability of probiotic strains in the gastrointestinal tract.
|
| ジャーナル |
Appl Environ Microbiol
|
| Abstract |
The viability of probiotics in the human gastrointestinal tract is important, as some reports indicate that the health benefits of live bacteria are greater than those of dead ones. Therefore, the higher the viability of the probiotic strain, the better it may be. However, probiotic strains lose their viability due to gastrointestinal stress such as gastric acid and bile. This study provides an example of the use of co-culture or pH-controlled monoculture, which uses more stringent conditions (lower pH) than normal monoculture to produce probiotic strains that are more resistant to gastrointestinal stress. In addition, co-cultured beverages showed higher viability of the probiotic strain in the human gastrointestinal tract than monocultured beverages in our human study.
|
| 巻・号 |
89(12)
|
| ページ |
e0150223
|
| 公開日 |
2023-12-21
|
| DOI |
10.1128/aem.01502-23
|
| PMID |
38019024
|
| PMC |
PMC10734474
|
| MeSH |
Bacteria
Bile Acids and Salts / pharmacology
Coculture Techniques
Gastrointestinal Tract* / microbiology
Humans
Microbial Viability
Probiotics*
|
| リソース情報 |
| 一般微生物 |
JCM 1120
JCM 5813
JCM 8130 |
