論文 - 詳細
| RRC ID | 80227 |
|---|---|
| 著者 | Uehara A, Maekawa M, Nakagawa K. |
| タイトル | Enhanced intestinal barrier function as the mechanism of antibiotic growth promoters in feed additives. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
Antibiotic growth promoters (AGPs) are a cost-effective tool for improving livestock productivity. However, antimicrobial-resistant bacteria have emerged, and the search for alternatives to AGPs has consequently intensified. To identify these alternatives without the risk of the emergence of antimicrobial resistance, it is important to determine the mechanism of action of AGPs and, subsequently, search for compounds with similar properties. We investigated the antimicrobial and anti-inflammatory activities and intestinal barrier function of several AGPs using epithelial and immune cells. At the minimum administered dose of antibiotics, which effectively function as a growth promoter, the mechanism of action is to enhance the intestinal barrier function, but not the antimicrobial activity as determined using Dunnett's test (n = 3, P < .05). Inflammatory response was dependent on the combination of antibiotics (100 µmol/L) and immune cells. The results suggest that future studies should screen for nonantibiotic compounds that ameliorate intestinal barrier function. |
| 巻・号 | 87(11) |
| ページ | 1381-1392 |
| 公開日 | 2023-10-25 |
| DOI | 10.1093/bbb/zbad110 |
| PII | 7273124 |
| PMID | 37704399 |
| MeSH | Anti-Bacterial Agents* / pharmacology Anti-Infective Agents* / pharmacology Anti-Inflammatory Agents / pharmacology Bacteria Promoter Regions, Genetic |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM1132 JCM1231 JCM5803 JCM11019 JCM1207 |