論文 - 詳細
| RRC ID | 80228 |
|---|---|
| 著者 | De Padua JC, Fukushima-Sakuno E, Ueno K, Dela Cruz TEE, Ishihara A. |
| タイトル | Isolation, structure elucidation, and biological activities of sesquiterpenes and phthalides from two edible mushrooms Pleurotus species. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
Antimicrobial compounds were purified from culture filtrates from 2 edible Pleurotus species. Using a bioassay-guided fractionation of the culture filtrate extracts, 3 compounds (1-3) were obtained from Pleurotus ostreatus, and another compound (4) was obtained from Pleurotus pulmonarius. Spectroscopic analysis revealed that 1-3 was identified as 5,7-dimethoxyphthalide, 4,6-dimethoxyphthalide, and cheimonophyllon E, respectively, while 4 were identified as pleuroton A. The minimum inhibitory concentration and minimum bactericidal concentration of these compounds were determined against 6 pathogenic bacterial species, Enterococcus faecalis, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter cloacae. Compounds 2 and 4 were inhibitory against all tested bacteria, while 1 and 4 were inhibitory against 3 and 2 species, respectively. In addition, 1-4 inhibited tyrosinase, with IC50 values of 0.10-0.30 mg/mL, and α-glucosidase, with IC50 values of 0.12-0.54 mg/mL. However, their antioxidant capacities were marginal. |
| 巻・号 | 87(12) |
| ページ | 1429-1441 |
| 公開日 | 2023-11-21 |
| DOI | 10.1093/bbb/zbad126 |
| PII | 7259888 |
| PMID | 37667536 |
| MeSH | Agaricales* / chemistry Anti-Bacterial Agents / pharmacology Anti-Infective Agents* / pharmacology Bacteria Microbial Sensitivity Tests Pleurotus* Sesquiterpenes* / chemistry |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 5803 JCM 2151 JCM 1662 JCM 6841 JCM 5962 JCM 20208 |