Reference - Detail
RRC ID | 80507 |
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Author | Uemura M, Kobayashi K, Sato N, Nagai K, Seki R, Kamio M, Fukuda T, Tsubouchi T, Tomoda H, Ohshiro T, Kobayashi T, Terahara T. |
Title | Haneummycin, a new 22-membered macrolide lactam antibiotic, produced by marine-derived Streptomyces sp. KM77-8. |
Journal | J Antibiot (Tokyo) |
Abstract |
A new antibiotic named haneummycin (1) was isolated from a culture broth of marine-derived Streptomyces sp. KM77-8 by solvent extraction and HPLC using a C4 column. The structure of 1 was elucidated including relative stereochemistry as a new 22-membered macrolide lactam associated with a cyclopentanone and three sugars by various spectroscopic analyses, such as MS and NMR. Compound 1 displayed significant antibacterial activities against Gram-positive bacteria including vancomycin-resistant Enterococcus faecium (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) with both MIC values of 8.0 µg ml-1. |
Volume | 76(11) |
Pages | 650-657 |
Published | 2023-11-1 |
DOI | 10.1038/s41429-023-00648-5 |
PII | 10.1038/s41429-023-00648-5 |
PMID | 37726436 |
MeSH | Anti-Bacterial Agents / chemistry Lactams / pharmacology Macrolides / pharmacology Methicillin-Resistant Staphylococcus aureus* Microbial Sensitivity Tests Streptomyces* / chemistry |
Resource | |
General Microbes | JCM 1649 JCM 15430 |