論文 - 詳細
| RRC ID | 80507 |
|---|---|
| 著者 | Uemura M, Kobayashi K, Sato N, Nagai K, Seki R, Kamio M, Fukuda T, Tsubouchi T, Tomoda H, Ohshiro T, Kobayashi T, Terahara T. |
| タイトル | Haneummycin, a new 22-membered macrolide lactam antibiotic, produced by marine-derived Streptomyces sp. KM77-8. |
| ジャーナル | J Antibiot (Tokyo) |
| Abstract |
A new antibiotic named haneummycin (1) was isolated from a culture broth of marine-derived Streptomyces sp. KM77-8 by solvent extraction and HPLC using a C4 column. The structure of 1 was elucidated including relative stereochemistry as a new 22-membered macrolide lactam associated with a cyclopentanone and three sugars by various spectroscopic analyses, such as MS and NMR. Compound 1 displayed significant antibacterial activities against Gram-positive bacteria including vancomycin-resistant Enterococcus faecium (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) with both MIC values of 8.0 µg ml-1. |
| 巻・号 | 76(11) |
| ページ | 650-657 |
| 公開日 | 2023-11-1 |
| DOI | 10.1038/s41429-023-00648-5 |
| PII | 10.1038/s41429-023-00648-5 |
| PMID | 37726436 |
| MeSH | Anti-Bacterial Agents* / chemistry Lactams* / pharmacology Macrolides* / pharmacology Methicillin-Resistant Staphylococcus aureus* Microbial Sensitivity Tests Streptomyces* / chemistry |
| リソース情報 | |
| 一般微生物 | JCM 1649 JCM 15430 |