RRC ID 80507
Author Uemura M, Kobayashi K, Sato N, Nagai K, Seki R, Kamio M, Fukuda T, Tsubouchi T, Tomoda H, Ohshiro T, Kobayashi T, Terahara T.
Title Haneummycin, a new 22-membered macrolide lactam antibiotic, produced by marine-derived Streptomyces sp. KM77-8.
Journal J Antibiot (Tokyo)
Abstract A new antibiotic named haneummycin (1) was isolated from a culture broth of marine-derived Streptomyces sp. KM77-8 by solvent extraction and HPLC using a C4 column. The structure of 1 was elucidated including relative stereochemistry as a new 22-membered macrolide lactam associated with a cyclopentanone and three sugars by various spectroscopic analyses, such as MS and NMR. Compound 1 displayed significant antibacterial activities against Gram-positive bacteria including vancomycin-resistant Enterococcus faecium (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) with both MIC values of 8.0 µg ml-1.
Volume 76(11)
Pages 650-657
Published 2023-11-1
DOI 10.1038/s41429-023-00648-5
PII 10.1038/s41429-023-00648-5
PMID 37726436
MeSH Anti-Bacterial Agents / chemistry Lactams / pharmacology Macrolides / pharmacology Methicillin-Resistant Staphylococcus aureus* Microbial Sensitivity Tests Streptomyces* / chemistry
Resource
General Microbes JCM 1649 JCM 15430