Reference - Detail
| RRC ID | 80529 |
|---|---|
| Author | Okamoto M, Miura A, Ito R, Kamada T, Mizukami Y, Kawamoto K. |
| Title | G-protein-coupled estrogen receptor prevents nuclear factor-kappa B promoter activation by Helicobacter pylori cytotoxin-associated gene A in gastric cancer cells. |
| Journal | J Vet Med Sci |
| Abstract |
Helicobacter pylori is a well-known pathogen that causes chronic gastritis, leading to the development of gastric cancer. This bacterium has also been detected in dogs, and symptoms similar to those in humans have been reported. The cytotoxin-associated gene A (CagA) is involved in pathogenesis through aberrant activation of host signal transduction, including the nuclear factor-kappa B (NF-κB) pathway. We have previously shown the anti-inflammatory effect of the G-protein-coupled estrogen receptor (GPER) via inhibiting of NF-κB activation in several cells. Therefore, here, we investigated the effect of GPER on CagA-mediated NF-κB promoter activity and showed that CagA overexpression in gastric cancer cells activated the NF-κB reporter and induced interleukin 8 (il-8) expression, both of which were inhibited by the GPER agonist. |
| Volume | 85(12) |
| Pages | 1348-1354 |
| Published | 2023-12-27 |
| DOI | 10.1292/jvms.23-0054 |
| PMID | 37952974 |
| PMC | PMC10788165 |
| MeSH | Animals Cytotoxins / metabolism Dog Diseases* / metabolism Dogs GTP-Binding Proteins / metabolism Gastric Mucosa / metabolism Helicobacter Infections* / metabolism Helicobacter Infections* / veterinary Helicobacter pylori* / genetics Helicobacter pylori* / metabolism Humans Interleukin-8 / genetics NF-kappa B / metabolism Receptors, Estrogen / genetics Receptors, Estrogen / metabolism Stomach Neoplasms* / genetics Stomach Neoplasms* / metabolism Stomach Neoplasms* / veterinary |
| Resource | |
| General Microbes | JCM 12093 |