論文 - 詳細
| RRC ID | 80568 |
|---|---|
| 著者 | Wang X, Lin S, Wang L, Cao Z, Zhang M, Zhang Y, Liu R, Liu J. |
| タイトル | Versatility of bacterial outer membrane vesicles in regulating intestinal homeostasis. |
| ジャーナル | Sci Adv |
| Abstract |
Outer membrane vesicles (OMVs) play vital roles in bacterial communication both intraspecifically and interspecifically. However, extracellular mechanisms of gut microbiota-derived OMVs in the intestine remain poorly understood. Here, we report that OMVs released from Akkermansia muciniphila are able to (i) restore disturbed balance of the gut microbiota by selectively promoting the proliferation of beneficial bacteria through membrane fusion, (ii) elicit mucosal immunoglobulin A response by translocating into Peyer's patches and subsequently activating B cells and dendritic cells, and (iii) maintain the integrity of the intestinal barrier by entering intestinal epithelial cells to stimulate the expressions of tight junctions and mucus. We demonstrate that transplantation of gut microbiota-associated OMVs to the intestine can alleviate colitis and enhance anti-programmed cell death protein 1 therapy against colorectal cancer by regulating intestinal homeostasis. This work discloses the importance of gut microbiota-derived OMVs in intestinal ecology, providing an alternative target for disease intervention and treatment. |
| 巻・号 | 9(11) |
| ページ | eade5079 |
| 公開日 | 2023-3-17 |
| DOI | 10.1126/sciadv.ade5079 |
| PMID | 36921043 |
| PMC | PMC10017049 |
| MeSH | Bacterial Outer Membrane Colitis* / metabolism Epithelial Cells Extracellular Vesicles* / metabolism Humans Intestines / microbiology |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 21 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 10556 |