Reference - Detail
| RRC ID | 80600 |
|---|---|
| Author | Ye H, Borusak S, Eberl C, Krasenbrink J, Weiss AS, Chen SC, Hanson BT, Hausmann B, Herbold CW, Pristner M, Zwirzitz B, Warth B, Pjevac P, Schleheck D, Stecher B, Loy A. |
| Title | Ecophysiology and interactions of a taurine-respiring bacterium in the mouse gut. |
| Journal | Nat Commun |
| Abstract |
Taurine-respiring gut bacteria produce H2S with ambivalent impact on host health. We report the isolation and ecophysiological characterization of a taurine-respiring mouse gut bacterium. Taurinivorans muris strain LT0009 represents a new widespread species that differs from the human gut sulfidogen Bilophila wadsworthia in its sulfur metabolism pathways and host distribution. T. muris specializes in taurine respiration in vivo, seemingly unaffected by mouse diet and genotype, but is dependent on other bacteria for release of taurine from bile acids. Colonization of T. muris in gnotobiotic mice increased deconjugation of taurine-conjugated bile acids and transcriptional activity of a sulfur metabolism gene-encoding prophage in other commensals, and slightly decreased the abundance of Salmonella enterica, which showed reduced expression of galactonate catabolism genes. Re-analysis of metagenome data from a previous study further suggested that T. muris can contribute to protection against pathogens by the commensal mouse gut microbiota. Together, we show the realized physiological niche of a key murine gut sulfidogen and its interactions with selected gut microbiota members. |
| Volume | 14(1) |
| Pages | 5533 |
| Published | 2023-9-18 |
| DOI | 10.1038/s41467-023-41008-z |
| PII | 10.1038/s41467-023-41008-z |
| PMID | 37723166 |
| PMC | PMC10507020 |
| MeSH | Affect* Animals Bile Acids and Salts Humans Mice Salmonella enterica* Sulfur Taurine |
| Altmetric score |
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 83 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| General Microbes | JCM 34262 |