論文 - 詳細
| RRC ID | 80603 |
|---|---|
| 著者 | Chen HC, Liu YW, Chang KC, Wu YW, Chen YM, Chao YK, You MY, Lundy DJ, Lin CJ, Hsieh ML, Cheng YC, Prajnamitra RP, Lin PJ, Ruan SC, Chen DH, Shih ESC, Chen KW, Chang SS, Chang CMC, Puntney R, Moy AW, Cheng YY, Chien HY, Lee JJ, Wu DC, Hwang MJ, Coonen J, Hacker TA, Yen CE, Rey FE, Kamp TJ, Hsieh PCH. |
| タイトル | Gut butyrate-producers confer post-infarction cardiac protection. |
| ジャーナル | Nat Commun |
| Abstract |
The gut microbiome and its metabolites are increasingly implicated in several cardiovascular diseases, but their role in human myocardial infarction (MI) injury responses have yet to be established. To address this, we examined stool samples from 77 ST-elevation MI (STEMI) patients using 16 S V3-V4 next-generation sequencing, metagenomics and machine learning. Our analysis identified an enriched population of butyrate-producing bacteria. These findings were then validated using a controlled ischemia/reperfusion model using eight nonhuman primates. To elucidate mechanisms, we inoculated gnotobiotic mice with these bacteria and found that they can produce beta-hydroxybutyrate, supporting cardiac function post-MI. This was further confirmed using HMGCS2-deficient mice which lack endogenous ketogenesis and have poor outcomes after MI. Inoculation increased plasma ketone levels and provided significant improvements in cardiac function post-MI. Together, this demonstrates a previously unknown role of gut butyrate-producers in the post-MI response. |
| 巻・号 | 14(1) |
| ページ | 7249 |
| 公開日 | 2023-11-9 |
| DOI | 10.1038/s41467-023-43167-5 |
| PII | 10.1038/s41467-023-43167-5 |
| PMID | 37945565 |
| PMC | PMC10636175 |
| MeSH | Animals Butyrates / metabolism Heart Humans Ketone Bodies Mice Myocardial Infarction* ST Elevation Myocardial Infarction* |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | |
| 各媒体での言及数の合計 | 50 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 1.0 |
| リソース情報 | |
| 一般微生物 | JCM15631 JCM9498 JCM31264 JCM6553 JCM15179 |