| RRC ID |
80687
|
| Author |
Taniguchi S, Nakayama S, Iguchi R, Sasakura Y, Satake H, Wada S, Suzuki N, Ogasawara M, Sekiguchi T.
|
| Title |
Distribution of cionin, a cholecystokinin/gastrin family peptide, and its receptor in the central nervous system of Ciona intestinalis type A.
|
| Journal |
Sci Rep
|
| Abstract |
The cholecystokinin (CCK)/gastrin family peptides are involved in regulation of feeding and digestion in vertebrates. In the ascidian Ciona intestinalis type A (Ciona robusta), cionin, a CCK/gastrin family peptide, has been identified. Cionin is expressed exclusively in the central nervous system (CNS). In contrast, cionin receptor expression has been detected in the CNS, digestive tract, and ovary. Although cionin has been reported to be involved in ovulation, its physiological function in the CNS remains to be investigated. To elucidate its neural function, in the present study, we analyzed the expression of cionin and cionin receptors in the CNS. Cionin was expressed mainly in neurons residing in the anterior region of the cerebral ganglion. In contrast, the gene expressin of the cionin receptor gene CioR1, was detected in the middle part of the cerebral ganglion and showed a similar expression pattern to that of VACHT, a cholinergic neuron marker gene. Moreover, CioR1 was found to be expressed in cholinergic neurons. Consequently, these results suggest that cionin interacts with cholinergic neurons as a neurotransmitter or neuromodulator via CioR1. This study provides insights into a biological role of a CCK/gastrin family peptide in the CNS of ascidians.
|
| Volume |
14(1)
|
| Pages |
6277
|
| Published |
2024-3-15
|
| DOI |
10.1038/s41598-024-55908-7
|
| PII |
10.1038/s41598-024-55908-7
|
| PMID |
38491056
|
| PMC |
PMC10942981
|
| MeSH |
Amino Acid Sequence
Animals
Central Nervous System
Cholecystokinin* / genetics
Cholecystokinin* / metabolism
Ciona intestinalis* / genetics
Ciona intestinalis* / metabolism
Female
Gastrins
Neuropeptides*
|
| IF |
3.998
|
| Resource |
| C.intestinalis / (O.japonicus) |
Wild C. int |
