Reference - Detail
| RRC ID | 80731 |
|---|---|
| Author | Hariri S, Li Q, Engebrecht J. |
| Title | 53bp1 mutation enhances brca1 and bard1 embryonic lethality in C. elegans. |
| Journal | MicroPubl Biol |
| Abstract |
In mice, mutation of brca1 results in embryonic lethality, which is partially suppressed by 53bp1 mutation. In contrast, mutation of the C. elegans BRCA1 ortholog, brc-1 , or its binding partner, brd-1 , lead to only mild embryonic lethality. We show that in C. elegans , brc-1 and brd-1 embryonic lethality is enhanced when 53bp1 ortholog, hsr-9 , is also mutated. This is not a consequence of activating polq-1 -dependent microhomology-mediated end joining, as polq-1 mutation does not suppress embryonic lethality of hsr-9 ; brc-1 mutants. Together, these results suggest that BRC-1 - BRD-1 and HSR-9 function in parallel pathways and do not act antagonistically as in mammals. |
| Volume | 2023 |
| Published | 2023-1-1 |
| DOI | 10.17912/micropub.biology.000934 |
| PMID | 37581122 |
| PMC | PMC10423319 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm1145 |