論文 - 詳細
| RRC ID | 80733 |
|---|---|
| 著者 | Kinney B, Sahu S, Stec N, Hills-Muckey K, Adams DW, Wang J, Jaremko M, Joshua-Tor L, Keil W, Hammell CM. |
| タイトル | A circadian-like gene network programs the timing and dosage of heterochronic miRNA transcription during C. elegans development. |
| ジャーナル | Dev Cell |
| Abstract |
Development relies on the exquisite control of both the timing and the levels of gene expression to achieve robust developmental transitions. How cis- and trans-acting factors control both aspects simultaneously is unclear. We show that transcriptional pulses of the temporal patterning microRNA (miRNA) lin-4 are generated by two nuclear hormone receptors (NHRs) in C. elegans, NHR-85 and NHR-23, whose mammalian orthologs, Rev-Erb and ROR, function in the circadian clock. Although Rev-Erb and ROR antagonize each other to control once-daily transcription in mammals, NHR-85/NHR-23 heterodimers bind cooperatively to lin-4 regulatory elements to induce a single pulse of expression during each larval stage. Each pulse's timing, amplitude, and duration are dictated by the phased expression of these NHRs and the C. elegans Period ortholog, LIN-42, that binds to and represses NHR-85. Therefore, during nematode temporal patterning, an evolutionary rewiring of circadian clock components couples the timing of gene expression to the control of transcriptional dosage. |
| 巻・号 | 58(22) |
| ページ | 2563-2579.e8 |
| 公開日 | 2023-11-20 |
| DOI | 10.1016/j.devcel.2023.08.006 |
| PII | S1534-5807(23)00402-1 |
| PMID | 37643611 |
| PMC | PMC10840721 |
| MeSH | Animals Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism Gene Expression Regulation, Developmental Gene Regulatory Networks Mammals / metabolism MicroRNAs* / genetics MicroRNAs* / metabolism Receptors, Cytoplasmic and Nuclear / metabolism Transcription Factors / genetics Transcription Factors / metabolism |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 20 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm4063 |