論文 - 詳細
| RRC ID | 80742 |
|---|---|
| 著者 | Ji H, Fouad AD, Li Z, Ruba A, Fang-Yen C. |
| タイトル | A proprioceptive feedback circuit drives Caenorhabditis elegans locomotor adaptation through dopamine signaling. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
An animal adapts its motor behavior to navigate the external environment. This adaptation depends on proprioception, which provides feedback on an animal's body postures. How proprioception mechanisms interact with motor circuits and contribute to locomotor adaptation remains unclear. Here, we describe and characterize proprioception-mediated homeostatic control of undulatory movement in the roundworm Caenorhabditis elegans. We found that the worm responds to optogenetically or mechanically induced decreases in midbody bending amplitude by increasing its anterior amplitude. Conversely, it responds to increased midbody amplitude by decreasing the anterior amplitude. Using genetics, microfluidic and optogenetic perturbation response analyses, and optical neurophysiology, we elucidated the neural circuit underlying this compensatory postural response. The dopaminergic PDE neurons proprioceptively sense midbody bending and signal to AVK interneurons via the D2-like dopamine receptor DOP-3. The FMRFamide-like neuropeptide FLP-1, released by AVK, regulates SMB head motor neurons to modulate anterior bending. We propose that this homeostatic behavioral control optimizes locomotor efficiency. Our findings demonstrate a mechanism in which proprioception works with dopamine and neuropeptide signaling to mediate motor control, a motif that may be conserved in other animals. |
| 巻・号 | 120(20) |
| ページ | e2219341120 |
| 公開日 | 2023-5-16 |
| DOI | 10.1073/pnas.2219341120 |
| PMID | 37155851 |
| PMC | PMC10193984 |
| MeSH | Animals Caenorhabditis elegans / physiology Caenorhabditis elegans Proteins* / genetics Dopamine / pharmacology Feedback, Sensory Locomotion / physiology Neuropeptides* / genetics |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 12 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.2 |
| リソース情報 | |
| 線虫 | tm5159 tm1392 tm1497 tm2706 |