論文 - 詳細
| RRC ID | 80748 |
|---|---|
| 著者 | Long L, Xu W, Valencia F, Paaby AB, McGrath PT. |
| タイトル | A toxin-antidote selfish element increases fitness of its host. |
| ジャーナル | Elife |
| Abstract |
Selfish genetic elements can promote their transmission at the expense of individual survival, creating conflict between the element and the rest of the genome. Recently, a large number of toxin-antidote (TA) post-segregation distorters have been identified in non-obligate outcrossing nematodes. Their origin and the evolutionary forces that keep them at intermediate population frequencies are poorly understood. Here, we study a TA element in Caenorhabditis elegans called zeel-1;peel-1. Two major haplotypes of this locus, with and without the selfish element, segregate in C. elegans. We evaluate the fitness consequences of the zeel-1;peel-1 element outside of its role in gene drive in non-outcrossing animals and demonstrate that loss of the toxin peel-1 decreased fitness of hermaphrodites and resulted in reductions in fecundity and body size. These findings suggest a biological role for peel-1 beyond toxin lethality. This work demonstrates that a TA element can provide a fitness benefit to its hosts either during their initial evolution or by being co-opted by the animals following their selfish spread. These findings guide our understanding on how TA elements can remain in a population where gene drive is minimized, helping resolve the mystery of prevalent TA elements in selfing animals. |
| 巻・号 | 12 |
| 公開日 | 2023-10-24 |
| DOI | 10.7554/eLife.81640 |
| PII | 81640 |
| PMID | 37874324 |
| PMC | PMC10629817 |
| MeSH | Animals Antidotes Caenorhabditis elegans / genetics Caenorhabditis elegans Proteins* / genetics Fertility Gene Frequency Repetitive Sequences, Nucleic Acid Toxins, Biological* |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.2 |
| リソース情報 | |
| 線虫 | tm229 tm377 tm409 tm1000 tm1001 tm1003 tm1004 tm1005 tm1006 tm573 |